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Lion's Mane Mushroom 13:1 Extract Capsules Organic high quality >30% polysaccharides >30% Polysaccharides >15% Beta Glucans EU and USDA Certified Organic Pure and potent extract, nothing added. Take 10% off your first order when you subscribe to the Nootropics Depot newsletter. 100% Organic Lions Mane Mushroom Supplement Description Supplement Facts Dosage Hot water extracted from 100% Lion's Mane mushrooms Still contains all non-water soluble components Made from … Lion’s mane mushroom’s immune regulating property may be of concern to individuals with autoimmune disorders. The few studies conducted report no adverse hematological or morphological changes based on subchronic rodent toxicity tests, and no mutagenicity or genotoxicity based on standard reverse mutation, chromosomal aberration, and micronuclei tests.Lakshmanan 2016, Li 2014, Li 2014, Studies in rodents have reported "no-observed-adverse-effect levels" of greater than 1 g/kg and greater than 3 g/kg body weight per day of erinacine A–enriched H. erinaceusLakshmanan 2016, Li 2014; the no-observed-adverse-effect level of greater than 1 g/kg equates to approximately 11.3 g/day for a 70 kg adult.Lakshmanan 2016. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Also known as Yamabushitake, Lion's Mane contains a wide range of varying polysaccharides. We comply with the HONcode standard for trustworthy health information -. Get it as soon as Fri, Jan 29. Although there are no reports of it slowing blood clotting in humans, patients with bleeding conditions or patients going into surgery should be careful about consuming it (x). Lion’s mane mushroom extracts were fed to seven test groups of rats, each on a high-fat diet. Lions Mane Extract is the premier organic lions mane mushroom extract powder with guaranteed potency by scientific analysis and free from fillers like grain. Organic Lions Mane extract powder made from a 12:1 water extraction. Lowering the number of lipids in blood plasma is one way to treat hypertension (high blood pressure) and can even prevent the start of diabetes. No one probably ever guessed that a mushroom could look like the mane of a lion. Lion's Mane Mushroom Extract Capsules Lion's Mane Mushroom 8:1 Dual Extract Capsules. Consuming it resulted in a huge decrease in serum glucose levels and an increase in serum insulin levels, concluding that the mushroom might help with managing diabetes (x). Not enough is known about the effects of lion’s mane mushroom on pregnant women or unborn fetuses, so pregnant patients should exercise caution and not use it. In this study, alcohol extract performed while water extract did not. The Black Pepper Fruit has been shown to unlock the potential of nutrients by increasing their bio-availability (rate at which your body can absorb and utilize these nutrients) by as much as 2000%! It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. These statements have not been evaluated by the Food and Drug Administration. Scientific Name(s): Hericium erinaceusCommon Name(s): Bear's head mushroom, Bearded hedgehog mushroom, Bearded tooth fungus/mushroom, Hog head fungus, Hou tou gu (Chinese), Lion's mane mushroom, Monkey head mushroom, Old man's beard mushroom, Pom pom mushroom, Satyr's beard fungus, White beard mushroom, Yamabushitake (Japanese). PURE LIONS MANE MUSHROOM EXTRACT POWDER: Made exclusively from 100% organic lions mane mushrooms. Evidence suggests that oxidative stress caused by free radical production can help diabetic complications progress in the body. beta-glucans, glycoproteins, and other high-molecular weight compounds). The company is an industry-leading manufacturer and distributor for pure dietary supplements. You should talk with your health care provider for complete information about the risks and benefits of using this product. A purified hot water extraction breaks down the cell walls and releases these compounds. Artificial cultivation has been described. Similar to heart health, much research on lion’s mane mushroom effects on cognitive health has been animal-based, but the results remain positive. 9 Health Benefits of Lion's Mane Mushroom (Plus Side Effects) Liquid Solutions. 4.7 Based on 126 Reviews. Information regarding safety and efficacy in pregnancy and lactation is lacking. If a patient wishes to consume a raw mushroom, some sources suggest cooking the outside until it is crispy, since the raw taste can be bitter (x). With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. A 2016 study from the Key Laboratory of Applied Mycological Resources and Utilization looked at different extracts of it for antibacterial activity, and it was found to inhibit several common bacteria found in the gut (x). Lion’s mane mushroom side effects seem to be few and far between. Some studies suggest that lion’s mane mushroom may help relieve symptoms associated with anxiety and depression. Use code BULK25 at checkout Mix and match your favorites . There were no adverse effects according to laboratory tests.Khan 2013, Mori 2009 A case series of 10 patients provided limited data regarding effects in patients with schizophrenia.Inanaga 2014, Limited studies have been conducted in rodents with induced diabetes. Studies have shown Lion's Mane mushrooms and the extract to be relatively safe for consumption at even large doses. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Ingredients: Lion’s Mane (From 5:1 Extract), Brown Rice Flour (Bulking Agent), Vegetarian Capsule (Hypromellose). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, clinical trials are lacking to support use of lion's mane mushroom for any indication. As we talked about above, many of the Lion’s Mane’s neuroprotective properties are due to compounds called triterpenes. It is not the roots (mycelium). For most people 1 – 2 capsules is the recommended daily dose. The fungus is able to absorb minerals from the cultivation media, including heavy metals.Jiang 2014, Lion's mane mushroom is widely consumed in Asian countries (China, India, Japan, and Korea) both for culinary and medicinal purposes. In clinical studies evaluating effects on cognitive function, the following dosages have been used: 750 mg/day of Yamabushitake (administered as a 250 mg tablet [containing 96% Yamabushitake dry powder] 3 times a day) for 16 weeksMori 2009; H. erinaceus in tablet form was administered as 3 g/day for 16 weeksWang 2014; and 5 g/day of the fruiting body was consumed in soup.Wang 2014. It can be found during late summer, particularly on American beech hardwood trees.Friedman 2015, He 2017 Synonyms of H. erinaceus include Clavaria erinaceus, Dryodon erinaceus, and Hydnum erinaceus. Lion’s Mane Mushroom consumed orally is well tolerated (please see below for information regarding drug interactions). Meanwhile, the water extract did not, nor did any of the other mushrooms tested. Elixirs came into popularity as part of the “brain-hacking” craze, which seeks to improve one or more of the brain’s functions. This information relates to an herbal, vitamin, mineral or other dietary supplement. A 2017 study looked at it’s effects on a healthy study group of mice, and the results showed an increase in recognition memory and overall cognitive health (x). "Friedman 2015, He 2017, Khan 2013 H. erinaceus has also been used as a fermentation substrate for production of mushroom wine and vinegar.Friedman 2015, Bioactive organic compounds have been identified in H. erinaceus fruiting bodies and mycelia, and include erinacines, other aromatic compounds (such as hericerin compounds), steroids, alkaloids, and lactones.Friedman 2015, Li 2015 Aromatic compounds produce the characteristic flavor and odor of H. erinaceus mushrooms, which have been described as seafood-like.Jiang 2014, The main polysaccharides identified include beta-glucans, alpha-glucans, and glucan-protein complexes. 3 ★ 6% . As a medicine, the dosages have lasted up to sixteen weeks. Lions Mane may become popular as a powerful nootropic due to it’s possible effect on brain function. It might also lower blood sugar. Brain Function . Hericenones a… It also supplies pure ingredients to other brands that distribute food and other supplement products. Superior Potency Divine Bounty’s formula offers the highest strength dose of Lions Mane extract per capsule at 600 mg per pill for a total of 1800mg per serving. Few clinical studies have been reported in the literature. Here's what Dave Asprey had to say to Tom Bilyeu about our Lion's Mane liquid extract on Impact Theory: More Information. In one study (1) the alcohol extract of lion’s mane increased NGF expression in 1321N1 human astrocytoma cells. These tests showed no adverse effects of consuming the mushroom, and that it may be effective in improving mild cognitive impairments (x). Decreased serum glucose and increased insulin have been demonstrated with aqueous extracts of H. erinaceus.Friedman 2015, Lakshmanan 2016, Liang 2013 Other studies have shown an improved lipid profileHiraki 2017 and relief from diabetic neuropathic pain.Yi 2015, Lion's mane mushroom polysaccharides diminished induced colitis and gastric mucosal lesions in rodents due to a combination of antioxidant and anti-inflammatory activity, as well as alteration in gut microbes.Diling 2017, Qin 2016, Ren 2018, Wang 2018, Wang 2018 In a study of ducklings infected with a retrovirus, H. erinaceus extract enhanced small intestinal mucosa repair and restored intestinal mucosal barrier functions.Wu 2018, A 1985 clinical study evaluated H. erinaceus extract in 50 patients with chronic atrophic gastritis over 3 months. Oral administration of the mushroom in mice has improved cognitive activity tests (x). Algae DHA Softgels (Vegan) Krill Oil Gelcaps. Triterpenes have to be released by soaking in alcohol. capsules ... Turkey Tail, Lion’s Mane and Shiitake are hot-water extracted to pull out polysaccharides (e.g. Dosages vary between different ages and health histories, so all patients considering taking lion’s mane mushroom supplements should consult a doctor first. Lion's mane mushrooms have been consumed in traditional folk medicine and medicinal cuisine. Consuming too much mushroom might produce an upset stomach, but nothing worse than that has been reported (x). This product is not intended to diagnose, treat, cure or prevent any disease. … If a package claims that the product will certainly provide specific health benefits, exercise caution, as much research so far has been animal-based. This chemical was administered to inflammation-induced mice, and the findings indicated that amycenone could potentially be used as a treatment for inflammation-related depression (x). Antiplatelet aggregation has been demonstrated in vitroFriedman 2015; however, no clinical data regarding any potential implications are available in the literature. It is a white, spherical fungus comprised of long, shaggy strands, growing on both dead and living broadleaf trees (x). Concentrations levels were reportedly higher in the experimental group, while irritation and anxiety were reportedly lower in the placebo group (x). When it comes to lion’s mane vs. cordyceps, which is right for you? That said, there is still the risk of allergies, and some have reported difficulty breathing or rashes after being exposed to the mushroom. Many health stores sell it as a supplement (x). Side Effects. Let’s weigh the health benefits of each functional mushroom extract so you can decide. All products at BulkSupplements.com are manufactured and tested according to current and proper manufacturing practices. Therefore, it seemed to have done the trick for the rats, lowering their cholesterol and lipid levels (x). One lion’s mane mushroom benefit is its antioxidative properties, which can assist with inflammation and strengthening the immune system. This information is not specific medical advice and does not replace information you receive from your health care provider. 5 ★ 81% . Lion’s mane is often cooked and eaten as a food or a powdered extract taken in capsule form. The Lion's Mane polysaccharides are … A group of mice was induced with colon cancer, and daily injections of lion’s mane mushroom extract for two weeks appeared to reduce the size of these tumors (x). Therefore, since the mushroom contains antioxidative properties, some research has been conducted into whether it might help lower blood sugar, which is the key to managing diabetes. 2. For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day. The mushroom has proven beneficial to cognitive health in Alzheimer’s models in rats, but not much research has been conducted on healthy subjects. With 30% beta glucans this extract is the real deal! This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you’re seeking rapid absorption by the digestive system, then Host Defense extracts may be the way to go. Although it has been consumed safely for centuries, a patient should talk to their doctor before using it as a supplement. Available for Android and iOS devices. Lion’s mane mushroom extracts contain active compounds such as Hericenone B which have anti-platelet activity; please take with caution in case of a bleeding disorder or if you are taking blood thinners. Other animal studies have linked this protein band to antitumor inhibition in mice, which help suggest that it might be a potential food ingredient for immunotherapy (x). $29.95 $ 29. A 2013 study from the Luqiao Hospital of Taizhou Enze Medical Center in China showed that consuming lion’s mane mushrooms can, at least in experimental animals, increase antioxidant enzyme activities (x). Host Defense, Lion's Mane Capsules, Promotes Mental Clarity, Focus and Memory, Daily Mushroom S… BulkSupplements.com is not just a consumer brand. Lions mane has long fungi that droop from the main head of the fungi giving the impression of lion’s mane, it’s generally found on hardwoods of fallen trees on hardwoods and a single clump of dangling spines. turmeric, saw palmetto, Ginkgo Biloba, garlic. For similar reasons, lion’s mane mushroom has been used to fight stomach ulcers in traditional Chinese medicine. Last updated on Nov 23, 2020. 8. Lion’s Mane elixirs allow for the body to absorb the mushrooms nutrients quicker vs. capsules or powders. When used orally and appropriately, it is considered possibly safe for short-term use. We do not add any mycelium, starch, grains, or fillers into our products. A 2012 study from the University of Malaya looked at antioxidative activities in culinary mushrooms and found that these mushrooms not only have good antioxidative activity but can also protect against hypertension and other heart-related problems (x). This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. The fruiting body contains contituents called beta glucans and polysaccharides which are the useful part that makes Lions Mane so legendary. There is little evidence to point to any side effects of a particular note. Softgels and Gelcaps. Lion’s mane and cordyceps are two of nature’s most potent medicinal mushrooms. (1) The active constituents (erinacines and hericenones) from lion’s mane encourage growth of branching axons, and in short more axons equals more rapid cognition. This is comparable to nerve growth factor (NGF) which means neurons grow and regenerate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. These triterpenes aren’t like the other components of Lion’s Mane, which are pulled out of the mushroom by hot water. The safety of long-term use is not known due to insufficient research and clinical studies. H. erinaceus is an edible fungus native to North America, Europe, and Asia. GI disturbances have been reported. They are extract with hot water to obtain the beneficial beta-glucans and hericinones, plus thousands of other nutrients from the mushroom. A 2011 study from the American Chemical Society looked at lion’s mane mushroom’s effect on colon cancer tumors. Ergosterol is transformed to vitamin D when exposed to UV-B light, a process used in commercially marketed vitamin D–containing mushrooms.Friedman 2015, In vitro, extracts of H. erinaceus have shown activity against human pathogenic bacteria, including some antibiotic-resistant strains,Friedman 2015 and against Helicobacter pylori.Friedman 2015, Liu 2016, Enhanced apoptosis and antiproliferative effects, including inhibition of angiogenic factors, have been demonstrated using human cancer cell lines and rodent models.Friedman 2015, He 2017, Jiang 2014, Li 2014, Antioxidant effects have been described.Friedman 2015, He 2017, Jiang 2014, Wang 2017 Studies in rodents suggest anti-ischemic effects of an H. erinaceus polysaccharide, with a decrease in serum urea nitrogen and serum creatinine compared with the control.Friedman 2015 Extracts of a mycelial culture of H. erinaceus positively influenced the lipid profile of dietary-induced hyperlipidemic and streptozotocin-induced diabetic rats.He 2017, Hiraki 2017, Jiang 2014, Khan 2013, Liang 2013 The chemical constituent hericenone B has demonstrated antiplatelet aggregation in vitro (in human and rabbit platelets) via inhibition of arachidonic acid release.Friedman 2015, Jiang 2014, Khan 2013 Lion's mane mushroom extract has also demonstrated angiotensin-converting enzyme inhibitory activity in vitro.Khan 2013, Neuroprotective effects of lion's mane mushroom have been demonstrated in vitro and in animal studies.Friedman 2015, He 2017, Khan 2013, Li 2018 In studies in mouse models of Alzheimer disease, dietary administration of H. erinaceus powder reduced spatial short-term and visual recognition memory impairment; inhibition of plaque growth, diminished activation of glial cells, and hippocampal neurogenesis have also been demonstrated.Brandalise 2017, Cheng 2016, Khan 2013, Tsai-Teng 2016, Tzeng 2018, Zhang 2016, In studies using mouse models of Parkinson disease, protective effects of H. erinaceus on neuronal cell cytotoxicity and apoptosis were reported to reverse motor deficits.Kuo 2016, Trovato 2016, The ethanol extract of H. erinaceus promoted nerve growth factor in vitro,Khan 2013, Zhang 2017, Zhang 2018 and in one study, peripheral nerve regeneration after injury was enhanced in rats.Wong 2016 When an extract of H. erinaceus was used in cultivated cerebellar cells, a regulatory effect on myelin genesis was reported.Jiang 2014, Khan 2013 Inhibition of cell senescence and accelerated wound healing in rats has also been demonstrated.Friedman 2015, Stress testing in mice has demonstrated antidepressant effects, including changes in proinflammatory cytokines and decreased levels of the neurotransmitters norepinephrine, dopamine, and serotonin.Chiu 2018 Decreased wakefulness occurred in a study of behavioral rhythm in mice.Furuta 2016 In a study using the forced swimming test in mice, H. erinaceus extract was protective, as evidenced by biochemical parameters related to fatigue.Liu 2015, Limited clinical studies have been conducted. 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